Watson: Beyond Jeopardy!

Watson: Beyond Jeopardy!

Article history: Received 28 May 2012 Accepted 23 June 2012 Available online 7 August 2012 This paper presents a vision for applying the Watson technology to health care and describes the steps needed to adapt and improve performance in a new domain. Specifically, it elaborates upon a vision for an evidence-based clinical decision support system, based on the DeepQA technology, that affords exp...

In the game: The interface between Watson and Jeopardy!

To play as a contestant in Jeopardy!i, IBM Watsoni needed an interface program to handle the communications between the Jeopardy! computers that operate the game and its own components: question answering, game strategy, speech, buzzer, etc. Because Watson cannot hear or see, when the categories and clues were displayed on the game board, they were also sent electronically to Watson. The progra...

RNA folding: beyond Watson-Crick pairs.

Several crystal structures of RNA fragments, alone or in complex with a specific protein, have been recently solved. In addition, the structures of an artificial ribozyme, the leadzyme, and the cleavage product of a human pathogen ribozyme, have extended the structural diversity of ribozyme architectures. The attained set of folding rules and motifs expand the repertoire seen previously in tRNA...

Double jeopardy?

Drug discovery in jeopardy.

Despite striking advances in the biomedical sciences, the flow of new drugs has slowed to a trickle, impairing therapeutic advances as well as the commercial success of drug companies. Reduced productivity in the drug industry is caused mainly by corporate policies that discourage innovation. This is compounded by various consequences of mega-mergers, the obsession for blockbuster drugs, the sh...